Methylene blue Injectable 100mg/mL 10mL Conquer Pharma Intravenous

Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondrial dysfunction has been observed in systematic aging that affects many different tissues, including the brain and skin. This leads to increased oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. This review summarizes the recent studies on the applications of MB in treating age-related conditions, including neurodegeneration, memory loss, skin aging, and a premature aging disease, progeria.

According to the free radicals theory of aging, cell and tissue aging are a result of free radicals’ attacks .In human cells, reactive oxygen species (ROS) are mainly produced in mitochondria, while aging, declines in mitochondrial mass, respiration capacity, and respiration efficiency were observed in different tissues. Dysfunctional mitochondria lead to decreased ATP production and increased ROS production, which would further damage mitochondria. This vicious cycle leads to severe cellular damages and accelerates the aging process. MB’s antioxidative properties mainly improve mitochondrial function and break the ROS–mitochondrial damage cycle, which makes it a great candidate as an anti-aging drug.