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Questions and answers about high dose vitamin C

What is the high dose of vitamin C?

Vitamin C is a nutrient found in foods, such as oranges, grapefruits, papayas, bell peppers, and kale, or in dietary supplements. Vitamin C is an antioxidant and helps prevent damage to cells caused by free radicals. It also works with enzymes to play a key role in collagen production. Vitamin C is also called L-ascorbic acid or ascorbate.

How are high doses of vitamin C administered or taken?

Vitamin C can be administered by intravenous infusion or orally. Much higher blood levels are achieved when vitamin C is administered intravenously. When administered by intravenous (IV) infusion, vitamin C can reach higher levels in the blood than when taken orally.

Have studies of high doses of vitamin C been performed in people?

IV vitamin C studies alone

Two studies found that patients who received IV vitamin C had a better quality of life and fewer side effects than those who did not.

In a study of healthy volunteers and cancer patients, vitamin C was shown to be safe at doses up to 1.5 g / kg in patients without kidney stones, other kidney disease, or G6PD deficiency.

Vitamin C IV studies combined with other drugs.

In a small study of 9 patients with advanced pancreatic cancer, patients received chemotherapy once a week for 3 weeks along with IV vitamin C twice a week for 4 weeks during each treatment cycle. The disease did not progress an average of 6 months in these patients. No serious side effects were reported with the combination treatment.

In a 2014 study of 27 patients with advanced ovarian cancer, chemotherapy alone was compared to chemotherapy and vitamin C IV. Vitamin C was administered during chemotherapy and for 6 months after chemotherapy ended. Patients who received IV vitamin C had fewer side effects from chemotherapy.

Patients with non-small cell lung cancer or glioblastoma multiforme in two pilot trials were given standard therapy plus IV vitamin C. Patients had better overall survival and fewer side effects compared to the control groups.