Possible Side Effects
Side effects of SAMe are minor but include nausea and digestive issues. Large amounts of SAMe may cause mania (an abnormally elevated mood). There’s also some concern that the use of SAMe can trigger an allergic reaction in some people.1
Interactions
If you have bipolar disorder, Lesch-Nyhan syndrome, Parkinson’s disease, or other health conditions, you should only use SAMe under the supervision of your healthcare provider as it may worsen symptoms. 1
It’s important to note that there may be risks when combining SAMe with medication or other supplements. You shouldn’t take SAMe in combination with antidepressants, cough medicine, diabetes medication, levodopa (L-dopa), L-tryptophan, medications that affects serotonin levels, St. John’s wort, or other medication unless you are being monitored by a health professional. SAMe should be discontinued at least two weeks before a scheduled surgery.
The safety of SAMe in children, pregnant or nursing women, or people with kidney or liver disease hasn’t been established.1 You can get tips on using supplements safely, but you should speak with your primary care provider before taking SAMe to discuss whether it’s appropriate for you. Keep in mind that SAMe shouldn’t be used as a substitute for standard treatment.
Dosage and Preparation
SAMe supplements are sold as capsules, tablets, and powder. Typically, doses of 200 mg to 800 mg, and up to 1600mg, are used, depending on the condition.
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